diff --git a/comfy/ops.py b/comfy/ops.py
index 81a97a30b..8c0aaec55 100644
--- a/comfy/ops.py
+++ b/comfy/ops.py
@@ -975,6 +975,7 @@ def pick_operations(weight_dtype, compute_dtype, load_device=None, disable_fast_
         if not fp8_compute:
             disabled.add("float8_e4m3fn")
             disabled.add("float8_e5m2")
+            disabled.add("mxfp8")
         return mixed_precision_ops(model_config.quant_config, compute_dtype, disabled=disabled)
 
     if (
diff --git a/comfy/quant_ops.py b/comfy/quant_ops.py
index 43c6fd7ce..76e755c5f 100644
--- a/comfy/quant_ops.py
+++ b/comfy/quant_ops.py
@@ -38,6 +38,9 @@ except ImportError as e:
     class _CKNvfp4Layout:
         pass
 
+    class _CKMxfp8Layout:
+        pass
+
     def register_layout_class(name, cls):
         pass
 
@@ -138,7 +141,8 @@ register_layout_class("TensorCoreFP8Layout", TensorCoreFP8Layout)
 register_layout_class("TensorCoreFP8E4M3Layout", TensorCoreFP8E4M3Layout)
 register_layout_class("TensorCoreFP8E5M2Layout", TensorCoreFP8E5M2Layout)
 register_layout_class("TensorCoreNVFP4Layout", TensorCoreNVFP4Layout)
-register_layout_class("TensorCoreMXFP8Layout", TensorCoreMXFP8Layout)
+if _CK_AVAILABLE:
+    register_layout_class("TensorCoreMXFP8Layout", TensorCoreMXFP8Layout)
 
 QUANT_ALGOS = {
     "float8_e4m3fn": {