diff --git a/comfy/model_base.py b/comfy/model_base.py
index e877f19ac..7c788d085 100644
--- a/comfy/model_base.py
+++ b/comfy/model_base.py
@@ -134,7 +134,7 @@ class BaseModel(torch.nn.Module):
         if not unet_config.get("disable_unet_model_creation", False):
             if model_config.custom_operations is None:
                 fp8 = model_config.optimizations.get("fp8", False)
-                operations = comfy.ops.pick_operations(unet_config.get("dtype", None), self.manual_cast_dtype, fp8_optimizations=fp8, scaled_fp8=model_config.scaled_fp8)
+                operations = comfy.ops.pick_operations(unet_config.get("dtype", None), self.manual_cast_dtype, fp8_optimizations=fp8, scaled_fp8=model_config.scaled_fp8, model_config=model_config)
             else:
                 operations = model_config.custom_operations
             self.diffusion_model = unet_model(**unet_config, device=device, operations=operations)
@@ -333,6 +333,14 @@ class BaseModel(torch.nn.Module):
         if self.model_config.scaled_fp8 is not None:
             unet_state_dict["scaled_fp8"] = torch.tensor([], dtype=self.model_config.scaled_fp8)
 
+        # Save mixed precision metadata
+        if hasattr(self.model_config, 'layer_quant_config') and self.model_config.layer_quant_config:
+            metadata = {
+                "format_version": "1.0",
+                "layers": self.model_config.layer_quant_config
+            }
+            unet_state_dict["_quantization_metadata"] = metadata
+
         unet_state_dict = self.model_config.process_unet_state_dict_for_saving(unet_state_dict)
 
         if self.model_type == ModelType.V_PREDICTION:
diff --git a/comfy/model_detection.py b/comfy/model_detection.py
index 141f1e164..3142a7fc3 100644
--- a/comfy/model_detection.py
+++ b/comfy/model_detection.py
@@ -6,6 +6,20 @@ import math
 import logging
 import torch
 
+
+def detect_layer_quantization(metadata):
+    quant_key = "_quantization_metadata"
+    if metadata is not None and quant_key in metadata:
+        quant_metadata = metadata.pop(quant_key)
+        quant_metadata = json.loads(quant_metadata)
+        if isinstance(quant_metadata, dict) and "layers" in quant_metadata:
+            logging.info(f"Found quantization metadata (version {quant_metadata.get('format_version', 'unknown')})")
+            return quant_metadata["layers"]
+        else:
+            raise ValueError("Invalid quantization metadata format")
+    return None
+
+
 def count_blocks(state_dict_keys, prefix_string):
     count = 0
     while True:
@@ -701,6 +715,12 @@ def model_config_from_unet(state_dict, unet_key_prefix, use_base_if_no_match=Fal
         else:
             model_config.optimizations["fp8"] = True
 
+    # Detect per-layer quantization (mixed precision)
+    layer_quant_config = detect_layer_quantization(metadata)
+    if layer_quant_config:
+        model_config.layer_quant_config = layer_quant_config
+        logging.info(f"Detected mixed precision quantization: {len(layer_quant_config)} layers quantized")
+
     return model_config
 
 def unet_prefix_from_state_dict(state_dict):
diff --git a/comfy/ops.py b/comfy/ops.py
index 934e21261..93731eedf 100644
--- a/comfy/ops.py
+++ b/comfy/ops.py
@@ -344,6 +344,10 @@ class manual_cast(disable_weight_init):
 
 
 def fp8_linear(self, input):
+    """
+    Legacy FP8 linear function for backward compatibility.
+    Uses QuantizedTensor subclass for dispatch.
+    """
     dtype = self.weight.dtype
     if dtype not in [torch.float8_e4m3fn]:
         return None
@@ -355,9 +359,9 @@ def fp8_linear(self, input):
 
     input_shape = input.shape
     input_dtype = input.dtype
+
     if len(input.shape) == 3:
         w, bias = cast_bias_weight(self, input, dtype=dtype, bias_dtype=input_dtype)
-        w = w.t()
 
         scale_weight = self.scale_weight
         scale_input = self.scale_input
@@ -368,23 +372,18 @@ def fp8_linear(self, input):
 
         if scale_input is None:
             scale_input = torch.ones((), device=input.device, dtype=torch.float32)
-            input = torch.clamp(input, min=-448, max=448, out=input)
-            input = input.reshape(-1, input_shape[2]).to(dtype).contiguous()
         else:
             scale_input = scale_input.to(input.device)
-            input = (input * (1.0 / scale_input).to(input_dtype)).reshape(-1, input_shape[2]).to(dtype).contiguous()
 
-        if bias is not None:
-            o = torch._scaled_mm(input, w, out_dtype=input_dtype, bias=bias, scale_a=scale_input, scale_b=scale_weight)
-        else:
-            o = torch._scaled_mm(input, w, out_dtype=input_dtype, scale_a=scale_input, scale_b=scale_weight)
-
-        if isinstance(o, tuple):
-            o = o[0]
+        # Wrap weight in QuantizedTensor - this enables unified dispatch
+        # Call F.linear - __torch_dispatch__ routes to fp8_linear handler in quant_ops.py!
+        layout_params_weight = {'scale': scale_weight, 'orig_dtype': input_dtype}
+        quantized_weight = QuantizedTensor(w, TensorCoreFP8Layout, layout_params_weight)
+        quantized_input = QuantizedTensor.from_float(input.reshape(-1, input_shape[2]), TensorCoreFP8Layout, scale=scale_input, dtype=dtype)
+        o = torch.nn.functional.linear(quantized_input, quantized_weight, bias)
 
         if tensor_2d:
             return o.reshape(input_shape[0], -1)
-
         return o.reshape((-1, input_shape[1], self.weight.shape[0]))
 
     return None
@@ -478,7 +477,128 @@ if CUBLAS_IS_AVAILABLE:
             def forward(self, *args, **kwargs):
                 return super().forward(*args, **kwargs)
 
-def pick_operations(weight_dtype, compute_dtype, load_device=None, disable_fast_fp8=False, fp8_optimizations=False, scaled_fp8=None):
+
+# ==============================================================================
+# Mixed Precision Operations
+# ==============================================================================
+from .quant_ops import QuantizedTensor, TensorCoreFP8Layout
+
+QUANT_FORMAT_MIXINS = {
+    "float8_e4m3fn": {
+        "dtype": torch.float8_e4m3fn,
+        "layout_type": TensorCoreFP8Layout,
+        "parameters": {
+            "weight_scale": torch.nn.Parameter(torch.zeros((), dtype=torch.float32), requires_grad=False),
+            "input_scale": torch.nn.Parameter(torch.zeros((), dtype=torch.float32), requires_grad=False),
+        }
+    }
+}
+
+class MixedPrecisionOps(disable_weight_init):
+    _layer_quant_config = {}
+    _compute_dtype = torch.bfloat16
+
+    class Linear(torch.nn.Module, CastWeightBiasOp):
+        def __init__(
+            self,
+            in_features: int,
+            out_features: int,
+            bias: bool = True,
+            device=None,
+            dtype=None,
+        ) -> None:
+            super().__init__()
+
+            self.factory_kwargs = {"device": device, "dtype": MixedPrecisionOps._compute_dtype}
+            # self.factory_kwargs = {"device": device, "dtype": dtype}
+
+            self.in_features = in_features
+            self.out_features = out_features
+            if bias:
+                self.bias = torch.nn.Parameter(torch.empty(out_features, **self.factory_kwargs))
+            else:
+                self.register_parameter("bias", None)
+
+            self.tensor_class = None
+
+        def reset_parameters(self):
+            return None
+
+        def _load_from_state_dict(self, state_dict, prefix, local_metadata,
+                                  strict, missing_keys, unexpected_keys, error_msgs):
+
+            device = self.factory_kwargs["device"]
+            layer_name = prefix.rstrip('.')
+            weight_key = f"{prefix}weight"
+            weight = state_dict.pop(weight_key, None)
+            if weight is None:
+                raise ValueError(f"Missing weight for layer {layer_name}")
+
+            manually_loaded_keys = [weight_key]
+
+            if layer_name not in MixedPrecisionOps._layer_quant_config:
+                self.weight = torch.nn.Parameter(weight.to(device=device, dtype=MixedPrecisionOps._compute_dtype), requires_grad=False)
+            else:
+                quant_format = MixedPrecisionOps._layer_quant_config[layer_name].get("format", None)
+                if quant_format is None:
+                    raise ValueError(f"Unknown quantization format for layer {layer_name}")
+
+                mixin = QUANT_FORMAT_MIXINS[quant_format]
+                self.layout_type = mixin["layout_type"]
+
+                scale_key = f"{prefix}weight_scale"
+                layout_params = {
+                    'scale': state_dict.pop(scale_key, None),
+                    'orig_dtype': MixedPrecisionOps._compute_dtype
+                }
+                if layout_params['scale'] is not None:
+                    manually_loaded_keys.append(scale_key)
+
+                self.weight = torch.nn.Parameter(
+                    QuantizedTensor(weight.to(device=device, dtype=mixin["dtype"]), self.layout_type, layout_params),
+                    requires_grad=False
+                )
+
+                for param_name, param_value in mixin["parameters"].items():
+                    param_key = f"{prefix}{param_name}"
+                    _v = state_dict.pop(param_key, None)
+                    if _v is None:
+                        continue
+                    setattr(self, param_name, torch.nn.Parameter(_v.to(device=device), requires_grad=False))
+                    manually_loaded_keys.append(param_key)
+
+            super()._load_from_state_dict(state_dict, prefix, local_metadata, strict, missing_keys, unexpected_keys, error_msgs)
+
+            for key in manually_loaded_keys:
+                if key in missing_keys:
+                    missing_keys.remove(key)
+
+        def _forward(self, input, weight, bias):
+            return torch.nn.functional.linear(input, weight, bias)
+
+        def forward_comfy_cast_weights(self, input):
+            weight, bias = cast_bias_weight(self, input)
+            return self._forward(input, weight, bias)
+
+        def forward(self, input, *args, **kwargs):
+            run_every_op()
+
+            if self.comfy_cast_weights or len(self.weight_function) > 0 or len(self.bias_function) > 0:
+                return self.forward_comfy_cast_weights(input, *args, **kwargs)
+            if (getattr(self, 'layout_type', None) is not None and
+                getattr(self, 'input_scale', None) is not None and
+                not isinstance(input, QuantizedTensor)):
+                input = QuantizedTensor.from_float(input, self.layout_type, scale=self.input_scale, fp8_dtype=self.weight.dtype)
+            return self._forward(input, self.weight, self.bias)
+
+
+def pick_operations(weight_dtype, compute_dtype, load_device=None, disable_fast_fp8=False, fp8_optimizations=False, scaled_fp8=None, model_config=None):
+    if model_config and hasattr(model_config, 'layer_quant_config') and model_config.layer_quant_config:
+        MixedPrecisionOps._layer_quant_config = model_config.layer_quant_config
+        MixedPrecisionOps._compute_dtype = compute_dtype
+        logging.info(f"Using mixed precision operations: {len(model_config.layer_quant_config)} quantized layers")
+        return MixedPrecisionOps
+
     fp8_compute = comfy.model_management.supports_fp8_compute(load_device)
     if scaled_fp8 is not None:
         return scaled_fp8_ops(fp8_matrix_mult=fp8_compute and fp8_optimizations, scale_input=fp8_optimizations, override_dtype=scaled_fp8)
diff --git a/comfy/quant_ops.py b/comfy/quant_ops.py
new file mode 100644
index 000000000..b14e03084
--- /dev/null
+++ b/comfy/quant_ops.py
@@ -0,0 +1,437 @@
+import torch
+import logging
+from typing import Tuple, Dict
+
+_LAYOUT_REGISTRY = {}
+_GENERIC_UTILS = {}
+
+
+def register_layout_op(torch_op, layout_type):
+    """
+    Decorator to register a layout-specific operation handler.
+    Args:
+        torch_op: PyTorch operation (e.g., torch.ops.aten.linear.default)
+        layout_type: Layout class (e.g., TensorCoreFP8Layout)
+    Example:
+        @register_layout_op(torch.ops.aten.linear.default, TensorCoreFP8Layout)
+        def fp8_linear(func, args, kwargs):
+            # FP8-specific linear implementation
+            ...
+    """
+    def decorator(handler_func):
+        if torch_op not in _LAYOUT_REGISTRY:
+            _LAYOUT_REGISTRY[torch_op] = {}
+        _LAYOUT_REGISTRY[torch_op][layout_type] = handler_func
+        return handler_func
+    return decorator
+
+
+def register_generic_util(torch_op):
+    """
+    Decorator to register a generic utility that works for all layouts.
+    Args:
+        torch_op: PyTorch operation (e.g., torch.ops.aten.detach.default)
+
+    Example:
+        @register_generic_util(torch.ops.aten.detach.default)
+        def generic_detach(func, args, kwargs):
+            # Works for any layout
+            ...
+    """
+    def decorator(handler_func):
+        _GENERIC_UTILS[torch_op] = handler_func
+        return handler_func
+    return decorator
+
+
+def _get_layout_from_args(args):
+    for arg in args:
+        if isinstance(arg, QuantizedTensor):
+            return arg._layout_type
+        elif isinstance(arg, (list, tuple)):
+            for item in arg:
+                if isinstance(item, QuantizedTensor):
+                    return item._layout_type
+    return None
+
+
+def _move_layout_params_to_device(params, device):
+    new_params = {}
+    for k, v in params.items():
+        if isinstance(v, torch.Tensor):
+            new_params[k] = v.to(device=device)
+        else:
+            new_params[k] = v
+    return new_params
+
+
+def _copy_layout_params(params):
+    new_params = {}
+    for k, v in params.items():
+        if isinstance(v, torch.Tensor):
+            new_params[k] = v.clone()
+        else:
+            new_params[k] = v
+    return new_params
+
+
+class QuantizedLayout:
+    """
+    Base class for quantization layouts.
+
+    A layout encapsulates the format-specific logic for quantization/dequantization
+    and provides a uniform interface for extracting raw tensors needed for computation.
+
+    New quantization formats should subclass this and implement the required methods.
+    """
+    @classmethod
+    def quantize(cls, tensor, **kwargs) -> Tuple[torch.Tensor, Dict]:
+        raise NotImplementedError(f"{cls.__name__} must implement quantize()")
+
+    @staticmethod
+    def dequantize(qdata, **layout_params) -> torch.Tensor:
+        raise NotImplementedError("TensorLayout must implement dequantize()")
+
+    @classmethod
+    def get_plain_tensors(cls, qtensor) -> torch.Tensor:
+        raise NotImplementedError(f"{cls.__name__} must implement get_plain_tensors()")
+
+
+class QuantizedTensor(torch.Tensor):
+    """
+    Universal quantized tensor that works with any layout.
+
+    This tensor subclass uses a pluggable layout system to support multiple
+    quantization formats (FP8, INT4, INT8, etc.) without code duplication.
+
+    The layout_type determines format-specific behavior, while common operations
+    (detach, clone, to) are handled generically.
+
+    Attributes:
+        _qdata: The quantized tensor data
+        _layout_type: Layout class (e.g., TensorCoreFP8Layout)
+        _layout_params: Dict with layout-specific params (scale, zero_point, etc.)
+    """
+
+    @staticmethod
+    def __new__(cls, qdata, layout_type, layout_params):
+        """
+        Create a quantized tensor.
+
+        Args:
+            qdata: The quantized data tensor
+            layout_type: Layout class (subclass of QuantizedLayout)
+            layout_params: Dict with layout-specific parameters
+        """
+        return torch.Tensor._make_subclass(cls, qdata, require_grad=False)
+
+    def __init__(self, qdata, layout_type, layout_params):
+        self._qdata = qdata.contiguous()
+        self._layout_type = layout_type
+        self._layout_params = layout_params
+
+    def __repr__(self):
+        layout_name = self._layout_type.__name__
+        param_str = ", ".join(f"{k}={v}" for k, v in list(self._layout_params.items())[:2])
+        return f"QuantizedTensor(shape={self.shape}, layout={layout_name}, {param_str})"
+
+    @property
+    def layout_type(self):
+        return self._layout_type
+
+    def __tensor_flatten__(self):
+        """
+        Tensor flattening protocol for proper device movement.
+        """
+        inner_tensors = ["_qdata"]
+        ctx = {
+            "layout_type": self._layout_type,
+        }
+
+        tensor_params = {}
+        non_tensor_params = {}
+        for k, v in self._layout_params.items():
+            if isinstance(v, torch.Tensor):
+                tensor_params[k] = v
+            else:
+                non_tensor_params[k] = v
+
+        ctx["tensor_param_keys"] = list(tensor_params.keys())
+        ctx["non_tensor_params"] = non_tensor_params
+
+        for k, v in tensor_params.items():
+            attr_name = f"_layout_param_{k}"
+            object.__setattr__(self, attr_name, v)
+            inner_tensors.append(attr_name)
+
+        return inner_tensors, ctx
+
+    @staticmethod
+    def __tensor_unflatten__(inner_tensors, ctx, outer_size, outer_stride):
+        """
+        Tensor unflattening protocol for proper device movement.
+        Reconstructs the QuantizedTensor after device movement.
+        """
+        layout_type = ctx["layout_type"]
+        layout_params = dict(ctx["non_tensor_params"])
+
+        for key in ctx["tensor_param_keys"]:
+            attr_name = f"_layout_param_{key}"
+            layout_params[key] = inner_tensors[attr_name]
+
+        return QuantizedTensor(inner_tensors["_q_data"], layout_type, layout_params)
+
+    @classmethod
+    def from_float(cls, tensor, layout_type, **quantize_kwargs) -> 'QuantizedTensor':
+        qdata, layout_params = layout_type.quantize(tensor, **quantize_kwargs)
+        return cls(qdata, layout_type, layout_params)
+
+    def dequantize(self) -> torch.Tensor:
+        return self._layout_type.dequantize(self._qdata, **self._layout_params)
+
+    @classmethod
+    def __torch_dispatch__(cls, func, types, args=(), kwargs=None):
+        kwargs = kwargs or {}
+
+        # Step 1: Check generic utilities first (detach, clone, to, etc.)
+        if func in _GENERIC_UTILS:
+            return _GENERIC_UTILS[func](func, args, kwargs)
+
+        # Step 2: Check layout-specific handlers (linear, matmul, etc.)
+        layout_type = _get_layout_from_args(args)
+        if layout_type and func in _LAYOUT_REGISTRY:
+            handler = _LAYOUT_REGISTRY[func].get(layout_type)
+            if handler:
+                return handler(func, args, kwargs)
+
+        # Step 3: Fallback to dequantization
+        if isinstance(args[0] if args else None, QuantizedTensor):
+            logging.info(f"QuantizedTensor: Unhandled operation {func}, falling back to dequantization. kwargs={kwargs}")
+        return cls._dequant_and_fallback(func, args, kwargs)
+
+    @classmethod
+    def _dequant_and_fallback(cls, func, args, kwargs):
+        def dequant_arg(arg):
+            if isinstance(arg, QuantizedTensor):
+                return arg.dequantize()
+            elif isinstance(arg, (list, tuple)):
+                return type(arg)(dequant_arg(a) for a in arg)
+            return arg
+
+        new_args = dequant_arg(args)
+        new_kwargs = dequant_arg(kwargs)
+        return func(*new_args, **new_kwargs)
+
+
+# ==============================================================================
+# Generic Utilities (Layout-Agnostic Operations)
+# ==============================================================================
+
+def _create_transformed_qtensor(qt, transform_fn):
+    new_data = transform_fn(qt._qdata)
+    new_params = _copy_layout_params(qt._layout_params)
+    return QuantizedTensor(new_data, qt._layout_type, new_params)
+
+
+def _handle_device_transfer(qt, target_device, target_dtype=None, target_layout=None, op_name="to"):
+    if target_dtype is not None and target_dtype != qt.dtype:
+        logging.warning(
+            f"QuantizedTensor: dtype conversion requested to {target_dtype}, "
+            f"but not supported for quantized tensors. Ignoring dtype."
+        )
+
+    if target_layout is not None and target_layout != torch.strided:
+        logging.warning(
+            f"QuantizedTensor: layout change requested to {target_layout}, "
+            f"but not supported. Ignoring layout."
+        )
+
+    # Handle device transfer
+    current_device = qt._qdata.device
+    if target_device is not None:
+        # Normalize device for comparison
+        if isinstance(target_device, str):
+            target_device = torch.device(target_device)
+        if isinstance(current_device, str):
+            current_device = torch.device(current_device)
+
+        if target_device != current_device:
+            logging.debug(f"QuantizedTensor.{op_name}: Moving from {current_device} to {target_device}")
+            new_q_data = qt._qdata.to(device=target_device)
+            new_params = _move_layout_params_to_device(qt._layout_params, target_device)
+            new_qt = QuantizedTensor(new_q_data, qt._layout_type, new_params)
+            logging.debug(f"QuantizedTensor.{op_name}: Created new tensor on {target_device}")
+            return new_qt
+
+    logging.debug(f"QuantizedTensor.{op_name}: No device change needed, returning original")
+    return qt
+
+
+@register_generic_util(torch.ops.aten.detach.default)
+def generic_detach(func, args, kwargs):
+    """Detach operation - creates a detached copy of the quantized tensor."""
+    qt = args[0]
+    if isinstance(qt, QuantizedTensor):
+        return _create_transformed_qtensor(qt, lambda x: x.detach())
+    return func(*args, **kwargs)
+
+
+@register_generic_util(torch.ops.aten.clone.default)
+def generic_clone(func, args, kwargs):
+    """Clone operation - creates a deep copy of the quantized tensor."""
+    qt = args[0]
+    if isinstance(qt, QuantizedTensor):
+        return _create_transformed_qtensor(qt, lambda x: x.clone())
+    return func(*args, **kwargs)
+
+
+@register_generic_util(torch.ops.aten._to_copy.default)
+def generic_to_copy(func, args, kwargs):
+    """Device/dtype transfer operation - handles .to(device) calls."""
+    qt = args[0]
+    if isinstance(qt, QuantizedTensor):
+        return _handle_device_transfer(
+            qt,
+            target_device=kwargs.get('device', None),
+            target_dtype=kwargs.get('dtype', None),
+            op_name="_to_copy"
+        )
+    return func(*args, **kwargs)
+
+
+@register_generic_util(torch.ops.aten.to.dtype_layout)
+def generic_to_dtype_layout(func, args, kwargs):
+    """Handle .to(device) calls using the dtype_layout variant."""
+    qt = args[0]
+    if isinstance(qt, QuantizedTensor):
+        return _handle_device_transfer(
+            qt,
+            target_device=kwargs.get('device', None),
+            target_dtype=kwargs.get('dtype', None),
+            target_layout=kwargs.get('layout', None),
+            op_name="to"
+        )
+    return func(*args, **kwargs)
+
+
+@register_generic_util(torch.ops.aten.copy_.default)
+def generic_copy_(func, args, kwargs):
+    qt_dest = args[0]
+    src = args[1]
+
+    if isinstance(qt_dest, QuantizedTensor):
+        if isinstance(src, QuantizedTensor):
+            # Copy from another quantized tensor
+            qt_dest._qdata.copy_(src._qdata)
+            qt_dest._layout_type = src._layout_type
+            qt_dest._layout_params = _copy_layout_params(src._layout_params)
+        else:
+            # Copy from regular tensor - just copy raw data
+            qt_dest._qdata.copy_(src)
+        return qt_dest
+    return func(*args, **kwargs)
+
+
+@register_generic_util(torch.ops.aten._has_compatible_shallow_copy_type.default)
+def generic_has_compatible_shallow_copy_type(func, args, kwargs):
+    return True
+
+# ==============================================================================
+# FP8 Layout + Operation Handlers
+# ==============================================================================
+class TensorCoreFP8Layout(QuantizedLayout):
+    """
+    Storage format:
+    - qdata: FP8 tensor (torch.float8_e4m3fn or torch.float8_e5m2)
+    - scale: Scalar tensor (float32) for dequantization
+    - orig_dtype: Original dtype before quantization (for casting back)
+    """
+    @classmethod
+    def quantize(cls, tensor, scale=None, dtype=torch.float8_e4m3fn):
+        orig_dtype = tensor.dtype
+
+        if scale is None:
+            scale = torch.amax(tensor.abs()) / torch.finfo(dtype).max
+
+        if not isinstance(scale, torch.Tensor):
+            scale = torch.tensor(scale)
+        scale = scale.to(device=tensor.device, dtype=torch.float32)
+
+        lp_amax = torch.finfo(dtype).max
+        tensor_scaled = tensor.float() / scale
+        torch.clamp(tensor_scaled, min=-lp_amax, max=lp_amax, out=tensor_scaled)
+        qdata = tensor_scaled.to(dtype, memory_format=torch.contiguous_format)
+
+        layout_params = {
+            'scale': scale,
+            'orig_dtype': orig_dtype
+        }
+        return qdata, layout_params
+
+    @staticmethod
+    def dequantize(qdata, scale, orig_dtype, **kwargs):
+        plain_tensor = torch.ops.aten._to_copy.default(qdata, dtype=orig_dtype)
+        return plain_tensor * scale
+
+    @classmethod
+    def get_plain_tensors(cls, qtensor):
+        return qtensor._qdata, qtensor._layout_params['scale']
+
+
+@register_layout_op(torch.ops.aten.linear.default, TensorCoreFP8Layout)
+def fp8_linear(func, args, kwargs):
+    input_tensor = args[0]
+    weight = args[1]
+    bias = args[2] if len(args) > 2 else None
+
+    if isinstance(input_tensor, QuantizedTensor) and isinstance(weight, QuantizedTensor):
+        plain_input, scale_a = TensorCoreFP8Layout.get_plain_tensors(input_tensor)
+        plain_weight, scale_b = TensorCoreFP8Layout.get_plain_tensors(weight)
+
+        out_dtype = kwargs.get("out_dtype")
+        if out_dtype is None:
+            out_dtype = input_tensor._layout_params['orig_dtype']
+
+        weight_t = plain_weight.t()
+
+        tensor_2d = False
+        if len(plain_input.shape) == 2:
+            tensor_2d = True
+            plain_input = plain_input.unsqueeze(1)
+
+        input_shape = plain_input.shape
+        if len(input_shape) != 3:
+            return None
+
+        try:
+            output = torch._scaled_mm(
+                plain_input.reshape(-1, input_shape[2]),
+                weight_t,
+                bias=bias,
+                scale_a=scale_a,
+                scale_b=scale_b,
+                out_dtype=out_dtype,
+            )
+            if not tensor_2d:
+                output = output.reshape((-1, input_shape[1], weight.shape[0]))
+
+            if output.dtype in [torch.float8_e4m3fn, torch.float8_e5m2]:
+                output_scale = scale_a * scale_b
+                output_params = {
+                    'scale': output_scale,
+                    'orig_dtype': input_tensor._layout_params['orig_dtype']
+                }
+                return QuantizedTensor(output, TensorCoreFP8Layout, output_params)
+            else:
+                return output
+
+        except Exception as e:
+            raise RuntimeError(f"FP8 _scaled_mm failed, falling back to dequantization: {e}")
+
+    # Case 2: DQ Fallback
+    if isinstance(weight, QuantizedTensor):
+        weight = weight.dequantize()
+    if isinstance(input_tensor, QuantizedTensor):
+        input_tensor = input_tensor.dequantize()
+
+    return torch.nn.functional.linear(input_tensor, weight, bias)
diff --git a/comfy/sd.py b/comfy/sd.py
index 28bee248d..6411bb27d 100644
--- a/comfy/sd.py
+++ b/comfy/sd.py
@@ -1262,7 +1262,7 @@ def load_state_dict_guess_config(sd, output_vae=True, output_clip=True, output_c
     return (model_patcher, clip, vae, clipvision)
 
 
-def load_diffusion_model_state_dict(sd, model_options={}):
+def load_diffusion_model_state_dict(sd, model_options={}, metadata=None):
     """
     Loads a UNet diffusion model from a state dictionary, supporting both diffusers and regular formats.
 
@@ -1296,7 +1296,7 @@ def load_diffusion_model_state_dict(sd, model_options={}):
     weight_dtype = comfy.utils.weight_dtype(sd)
 
     load_device = model_management.get_torch_device()
-    model_config = model_detection.model_config_from_unet(sd, "")
+    model_config = model_detection.model_config_from_unet(sd, "", metadata=metadata)
 
     if model_config is not None:
         new_sd = sd
@@ -1330,7 +1330,10 @@ def load_diffusion_model_state_dict(sd, model_options={}):
     else:
         unet_dtype = dtype
 
-    manual_cast_dtype = model_management.unet_manual_cast(unet_dtype, load_device, model_config.supported_inference_dtypes)
+    if hasattr(model_config, "layer_quant_config"):
+        manual_cast_dtype = model_management.unet_manual_cast(None, load_device, model_config.supported_inference_dtypes)
+    else:
+        manual_cast_dtype = model_management.unet_manual_cast(unet_dtype, load_device, model_config.supported_inference_dtypes)
     model_config.set_inference_dtype(unet_dtype, manual_cast_dtype)
     model_config.custom_operations = model_options.get("custom_operations", model_config.custom_operations)
     if model_options.get("fp8_optimizations", False):
@@ -1346,8 +1349,8 @@ def load_diffusion_model_state_dict(sd, model_options={}):
 
 
 def load_diffusion_model(unet_path, model_options={}):
-    sd = comfy.utils.load_torch_file(unet_path)
-    model = load_diffusion_model_state_dict(sd, model_options=model_options)
+    sd, metadata = comfy.utils.load_torch_file(unet_path, return_metadata=True)
+    model = load_diffusion_model_state_dict(sd, model_options=model_options, metadata=metadata)
     if model is None:
         logging.error("ERROR UNSUPPORTED DIFFUSION MODEL {}".format(unet_path))
         raise RuntimeError("ERROR: Could not detect model type of: {}\n{}".format(unet_path, model_detection_error_hint(unet_path, sd)))
diff --git a/comfy/supported_models_base.py b/comfy/supported_models_base.py
index 54573abb1..e4bd74514 100644
--- a/comfy/supported_models_base.py
+++ b/comfy/supported_models_base.py
@@ -50,6 +50,7 @@ class BASE:
     manual_cast_dtype = None
     custom_operations = None
     scaled_fp8 = None
+    layer_quant_config = None  # Per-layer quantization configuration for mixed precision
     optimizations = {"fp8": False}
 
     @classmethod
diff --git a/tests-unit/comfy_quant/test_mixed_precision.py b/tests-unit/comfy_quant/test_mixed_precision.py
new file mode 100644
index 000000000..267bc177b
--- /dev/null
+++ b/tests-unit/comfy_quant/test_mixed_precision.py
@@ -0,0 +1,232 @@
+import unittest
+import torch
+import sys
+import os
+
+# Add comfy to path
+sys.path.insert(0, os.path.join(os.path.dirname(__file__), "..", ".."))
+
+def has_gpu():
+    return torch.cuda.is_available()
+
+from comfy.cli_args import args
+if not has_gpu():
+    args.cpu = True
+
+from comfy import ops
+from comfy.quant_ops import QuantizedTensor, TensorCoreFP8Layout
+
+
+class SimpleModel(torch.nn.Module):
+    def __init__(self, operations=ops.disable_weight_init):
+        super().__init__()
+        self.layer1 = operations.Linear(10, 20, device="cpu", dtype=torch.bfloat16)
+        self.layer2 = operations.Linear(20, 30, device="cpu", dtype=torch.bfloat16)
+        self.layer3 = operations.Linear(30, 40, device="cpu", dtype=torch.bfloat16)
+
+    def forward(self, x):
+        x = self.layer1(x)
+        x = torch.nn.functional.relu(x)
+        x = self.layer2(x)
+        x = torch.nn.functional.relu(x)
+        x = self.layer3(x)
+        return x
+
+
+class TestMixedPrecisionOps(unittest.TestCase):
+
+    def test_all_layers_standard(self):
+        """Test that model with no quantization works normally"""
+        # Configure no quantization
+        ops.MixedPrecisionOps._layer_quant_config = {}
+
+        # Create model
+        model = SimpleModel(operations=ops.MixedPrecisionOps)
+
+        # Initialize weights manually
+        model.layer1.weight = torch.nn.Parameter(torch.randn(20, 10, dtype=torch.bfloat16))
+        model.layer1.bias = torch.nn.Parameter(torch.randn(20, dtype=torch.bfloat16))
+        model.layer2.weight = torch.nn.Parameter(torch.randn(30, 20, dtype=torch.bfloat16))
+        model.layer2.bias = torch.nn.Parameter(torch.randn(30, dtype=torch.bfloat16))
+        model.layer3.weight = torch.nn.Parameter(torch.randn(40, 30, dtype=torch.bfloat16))
+        model.layer3.bias = torch.nn.Parameter(torch.randn(40, dtype=torch.bfloat16))
+
+        # Initialize weight_function and bias_function
+        for layer in [model.layer1, model.layer2, model.layer3]:
+            layer.weight_function = []
+            layer.bias_function = []
+
+        # Forward pass
+        input_tensor = torch.randn(5, 10, dtype=torch.bfloat16)
+        output = model(input_tensor)
+
+        self.assertEqual(output.shape, (5, 40))
+        self.assertEqual(output.dtype, torch.bfloat16)
+
+    def test_mixed_precision_load(self):
+        """Test loading a mixed precision model from state dict"""
+        # Configure mixed precision: layer1 is FP8, layer2 and layer3 are standard
+        layer_quant_config = {
+            "layer1": {
+                "format": "float8_e4m3fn",
+                "params": {}
+            },
+            "layer3": {
+                "format": "float8_e4m3fn",
+                "params": {}
+            }
+        }
+        ops.MixedPrecisionOps._layer_quant_config = layer_quant_config
+
+        # Create state dict with mixed precision
+        fp8_weight1 = torch.randn(20, 10, dtype=torch.float32).to(torch.float8_e4m3fn)
+        fp8_weight3 = torch.randn(40, 30, dtype=torch.float32).to(torch.float8_e4m3fn)
+
+        state_dict = {
+            # Layer 1: FP8 E4M3FN
+            "layer1.weight": fp8_weight1,
+            "layer1.bias": torch.randn(20, dtype=torch.bfloat16),
+            "layer1.weight_scale": torch.tensor(2.0, dtype=torch.float32),
+
+            # Layer 2: Standard BF16
+            "layer2.weight": torch.randn(30, 20, dtype=torch.bfloat16),
+            "layer2.bias": torch.randn(30, dtype=torch.bfloat16),
+
+            # Layer 3: FP8 E4M3FN
+            "layer3.weight": fp8_weight3,
+            "layer3.bias": torch.randn(40, dtype=torch.bfloat16),
+            "layer3.weight_scale": torch.tensor(1.5, dtype=torch.float32),
+        }
+
+        # Create model and load state dict (strict=False because custom loading pops keys)
+        model = SimpleModel(operations=ops.MixedPrecisionOps)
+        model.load_state_dict(state_dict, strict=False)
+
+        # Verify weights are wrapped in QuantizedTensor
+        self.assertIsInstance(model.layer1.weight, QuantizedTensor)
+        self.assertEqual(model.layer1.weight._layout_type, TensorCoreFP8Layout)
+
+        # Layer 2 should NOT be quantized
+        self.assertNotIsInstance(model.layer2.weight, QuantizedTensor)
+
+        # Layer 3 should be quantized
+        self.assertIsInstance(model.layer3.weight, QuantizedTensor)
+        self.assertEqual(model.layer3.weight._layout_type, TensorCoreFP8Layout)
+
+        # Verify scales were loaded
+        self.assertEqual(model.layer1.weight._layout_params['scale'].item(), 2.0)
+        self.assertEqual(model.layer3.weight._layout_params['scale'].item(), 1.5)
+
+        # Forward pass
+        input_tensor = torch.randn(5, 10, dtype=torch.bfloat16)
+        output = model(input_tensor)
+
+        self.assertEqual(output.shape, (5, 40))
+
+    def test_state_dict_quantized_preserved(self):
+        """Test that quantized weights are preserved in state_dict()"""
+        # Configure mixed precision
+        layer_quant_config = {
+            "layer1": {
+                "format": "float8_e4m3fn",
+                "params": {}
+            }
+        }
+        ops.MixedPrecisionOps._layer_quant_config = layer_quant_config
+
+        # Create and load model
+        fp8_weight = torch.randn(20, 10, dtype=torch.float32).to(torch.float8_e4m3fn)
+        state_dict1 = {
+            "layer1.weight": fp8_weight,
+            "layer1.bias": torch.randn(20, dtype=torch.bfloat16),
+            "layer1.weight_scale": torch.tensor(3.0, dtype=torch.float32),
+            "layer2.weight": torch.randn(30, 20, dtype=torch.bfloat16),
+            "layer2.bias": torch.randn(30, dtype=torch.bfloat16),
+            "layer3.weight": torch.randn(40, 30, dtype=torch.bfloat16),
+            "layer3.bias": torch.randn(40, dtype=torch.bfloat16),
+        }
+
+        model = SimpleModel(operations=ops.MixedPrecisionOps)
+        model.load_state_dict(state_dict1, strict=False)
+
+        # Save state dict
+        state_dict2 = model.state_dict()
+
+        # Verify layer1.weight is a QuantizedTensor with scale preserved
+        self.assertIsInstance(state_dict2["layer1.weight"], QuantizedTensor)
+        self.assertEqual(state_dict2["layer1.weight"]._layout_params['scale'].item(), 3.0)
+        self.assertEqual(state_dict2["layer1.weight"]._layout_type, TensorCoreFP8Layout)
+
+        # Verify non-quantized layers are standard tensors
+        self.assertNotIsInstance(state_dict2["layer2.weight"], QuantizedTensor)
+        self.assertNotIsInstance(state_dict2["layer3.weight"], QuantizedTensor)
+
+    def test_weight_function_compatibility(self):
+        """Test that weight_function (LoRA) works with quantized layers"""
+        # Configure FP8 quantization
+        layer_quant_config = {
+            "layer1": {
+                "format": "float8_e4m3fn",
+                "params": {}
+            }
+        }
+        ops.MixedPrecisionOps._layer_quant_config = layer_quant_config
+
+        # Create and load model
+        fp8_weight = torch.randn(20, 10, dtype=torch.float32).to(torch.float8_e4m3fn)
+        state_dict = {
+            "layer1.weight": fp8_weight,
+            "layer1.bias": torch.randn(20, dtype=torch.bfloat16),
+            "layer1.weight_scale": torch.tensor(2.0, dtype=torch.float32),
+            "layer2.weight": torch.randn(30, 20, dtype=torch.bfloat16),
+            "layer2.bias": torch.randn(30, dtype=torch.bfloat16),
+            "layer3.weight": torch.randn(40, 30, dtype=torch.bfloat16),
+            "layer3.bias": torch.randn(40, dtype=torch.bfloat16),
+        }
+
+        model = SimpleModel(operations=ops.MixedPrecisionOps)
+        model.load_state_dict(state_dict, strict=False)
+
+        # Add a weight function (simulating LoRA)
+        # This should trigger dequantization during forward pass
+        def apply_lora(weight):
+            lora_delta = torch.randn_like(weight) * 0.01
+            return weight + lora_delta
+
+        model.layer1.weight_function.append(apply_lora)
+
+        # Forward pass should work with LoRA (triggers weight_function path)
+        input_tensor = torch.randn(5, 10, dtype=torch.bfloat16)
+        output = model(input_tensor)
+
+        self.assertEqual(output.shape, (5, 40))
+
+    def test_error_handling_unknown_format(self):
+        """Test that unknown formats raise error"""
+        # Configure with unknown format
+        layer_quant_config = {
+            "layer1": {
+                "format": "unknown_format_xyz",
+                "params": {}
+            }
+        }
+        ops.MixedPrecisionOps._layer_quant_config = layer_quant_config
+
+        # Create state dict
+        state_dict = {
+            "layer1.weight": torch.randn(20, 10, dtype=torch.bfloat16),
+            "layer1.bias": torch.randn(20, dtype=torch.bfloat16),
+            "layer2.weight": torch.randn(30, 20, dtype=torch.bfloat16),
+            "layer2.bias": torch.randn(30, dtype=torch.bfloat16),
+            "layer3.weight": torch.randn(40, 30, dtype=torch.bfloat16),
+            "layer3.bias": torch.randn(40, dtype=torch.bfloat16),
+        }
+
+        # Load should raise KeyError for unknown format in QUANT_FORMAT_MIXINS
+        model = SimpleModel(operations=ops.MixedPrecisionOps)
+        with self.assertRaises(KeyError):
+            model.load_state_dict(state_dict, strict=False)
+
+if __name__ == "__main__":
+    unittest.main()
+
diff --git a/tests-unit/comfy_quant/test_quant_registry.py b/tests-unit/comfy_quant/test_quant_registry.py
new file mode 100644
index 000000000..477811029
--- /dev/null
+++ b/tests-unit/comfy_quant/test_quant_registry.py
@@ -0,0 +1,190 @@
+import unittest
+import torch
+import sys
+import os
+
+# Add comfy to path
+sys.path.insert(0, os.path.join(os.path.dirname(__file__), "..", ".."))
+
+def has_gpu():
+    return torch.cuda.is_available()
+
+from comfy.cli_args import args
+if not has_gpu():
+    args.cpu = True
+
+from comfy.quant_ops import QuantizedTensor, TensorCoreFP8Layout
+
+
+class TestQuantizedTensor(unittest.TestCase):
+    """Test the QuantizedTensor subclass with FP8 layout"""
+
+    def test_creation(self):
+        """Test creating a QuantizedTensor with TensorCoreFP8Layout"""
+        fp8_data = torch.randn(256, 128, dtype=torch.float32).to(torch.float8_e4m3fn)
+        scale = torch.tensor(2.0)
+        layout_params = {'scale': scale, 'orig_dtype': torch.bfloat16}
+
+        qt = QuantizedTensor(fp8_data, TensorCoreFP8Layout, layout_params)
+
+        self.assertIsInstance(qt, QuantizedTensor)
+        self.assertEqual(qt.shape, (256, 128))
+        self.assertEqual(qt.dtype, torch.float8_e4m3fn)
+        self.assertEqual(qt._layout_params['scale'], scale)
+        self.assertEqual(qt._layout_params['orig_dtype'], torch.bfloat16)
+        self.assertEqual(qt._layout_type, TensorCoreFP8Layout)
+
+    def test_dequantize(self):
+        """Test explicit dequantization"""
+
+        fp8_data = torch.ones(10, 20, dtype=torch.float32).to(torch.float8_e4m3fn)
+        scale = torch.tensor(3.0)
+        layout_params = {'scale': scale, 'orig_dtype': torch.float32}
+
+        qt = QuantizedTensor(fp8_data, TensorCoreFP8Layout, layout_params)
+        dequantized = qt.dequantize()
+
+        self.assertEqual(dequantized.dtype, torch.float32)
+        self.assertTrue(torch.allclose(dequantized, torch.ones(10, 20) * 3.0, rtol=0.1))
+
+    def test_from_float(self):
+        """Test creating QuantizedTensor from float tensor"""
+        float_tensor = torch.randn(64, 32, dtype=torch.float32)
+        scale = torch.tensor(1.5)
+
+        qt = QuantizedTensor.from_float(
+            float_tensor,
+            TensorCoreFP8Layout,
+            scale=scale,
+            dtype=torch.float8_e4m3fn
+        )
+
+        self.assertIsInstance(qt, QuantizedTensor)
+        self.assertEqual(qt.dtype, torch.float8_e4m3fn)
+        self.assertEqual(qt.shape, (64, 32))
+
+        # Verify dequantization gives approximately original values
+        dequantized = qt.dequantize()
+        mean_rel_error = ((dequantized - float_tensor).abs() / (float_tensor.abs() + 1e-6)).mean()
+        self.assertLess(mean_rel_error, 0.1)
+
+
+class TestGenericUtilities(unittest.TestCase):
+    """Test generic utility operations"""
+
+    def test_detach(self):
+        """Test detach operation on quantized tensor"""
+        fp8_data = torch.randn(10, 20, dtype=torch.float32).to(torch.float8_e4m3fn)
+        scale = torch.tensor(1.5)
+        layout_params = {'scale': scale, 'orig_dtype': torch.float32}
+        qt = QuantizedTensor(fp8_data, TensorCoreFP8Layout, layout_params)
+
+        # Detach should return a new QuantizedTensor
+        qt_detached = qt.detach()
+
+        self.assertIsInstance(qt_detached, QuantizedTensor)
+        self.assertEqual(qt_detached.shape, qt.shape)
+        self.assertEqual(qt_detached._layout_type, TensorCoreFP8Layout)
+
+    def test_clone(self):
+        """Test clone operation on quantized tensor"""
+        fp8_data = torch.randn(10, 20, dtype=torch.float32).to(torch.float8_e4m3fn)
+        scale = torch.tensor(1.5)
+        layout_params = {'scale': scale, 'orig_dtype': torch.float32}
+        qt = QuantizedTensor(fp8_data, TensorCoreFP8Layout, layout_params)
+
+        # Clone should return a new QuantizedTensor
+        qt_cloned = qt.clone()
+
+        self.assertIsInstance(qt_cloned, QuantizedTensor)
+        self.assertEqual(qt_cloned.shape, qt.shape)
+        self.assertEqual(qt_cloned._layout_type, TensorCoreFP8Layout)
+
+        # Verify it's a deep copy
+        self.assertIsNot(qt_cloned._qdata, qt._qdata)
+
+    @unittest.skipUnless(has_gpu(), "GPU not available")
+    def test_to_device(self):
+        """Test device transfer"""
+        fp8_data = torch.randn(10, 20, dtype=torch.float32).to(torch.float8_e4m3fn)
+        scale = torch.tensor(1.5)
+        layout_params = {'scale': scale, 'orig_dtype': torch.float32}
+        qt = QuantizedTensor(fp8_data, TensorCoreFP8Layout, layout_params)
+
+        # Moving to same device should work (CPU to CPU)
+        qt_cpu = qt.to('cpu')
+
+        self.assertIsInstance(qt_cpu, QuantizedTensor)
+        self.assertEqual(qt_cpu.device.type, 'cpu')
+        self.assertEqual(qt_cpu._layout_params['scale'].device.type, 'cpu')
+
+
+class TestTensorCoreFP8Layout(unittest.TestCase):
+    """Test the TensorCoreFP8Layout implementation"""
+
+    def test_quantize(self):
+        """Test quantization method"""
+        float_tensor = torch.randn(32, 64, dtype=torch.float32)
+        scale = torch.tensor(1.5)
+
+        qdata, layout_params = TensorCoreFP8Layout.quantize(
+            float_tensor,
+            scale=scale,
+            dtype=torch.float8_e4m3fn
+        )
+
+        self.assertEqual(qdata.dtype, torch.float8_e4m3fn)
+        self.assertEqual(qdata.shape, float_tensor.shape)
+        self.assertIn('scale', layout_params)
+        self.assertIn('orig_dtype', layout_params)
+        self.assertEqual(layout_params['orig_dtype'], torch.float32)
+
+    def test_dequantize(self):
+        """Test dequantization method"""
+        float_tensor = torch.ones(10, 20, dtype=torch.float32) * 3.0
+        scale = torch.tensor(1.0)
+
+        qdata, layout_params = TensorCoreFP8Layout.quantize(
+            float_tensor,
+            scale=scale,
+            dtype=torch.float8_e4m3fn
+        )
+
+        dequantized = TensorCoreFP8Layout.dequantize(qdata, **layout_params)
+
+        # Should approximately match original
+        self.assertTrue(torch.allclose(dequantized, float_tensor, rtol=0.1, atol=0.1))
+
+
+class TestFallbackMechanism(unittest.TestCase):
+    """Test fallback for unsupported operations"""
+
+    def test_unsupported_op_dequantizes(self):
+        """Test that unsupported operations fall back to dequantization"""
+        # Set seed for reproducibility
+        torch.manual_seed(42)
+
+        # Create quantized tensor
+        a_fp32 = torch.randn(10, 20, dtype=torch.float32)
+        scale = torch.tensor(1.0)
+        a_q = QuantizedTensor.from_float(
+            a_fp32,
+            TensorCoreFP8Layout,
+            scale=scale,
+            dtype=torch.float8_e4m3fn
+        )
+
+        # Call an operation that doesn't have a registered handler
+        # For example, torch.abs
+        result = torch.abs(a_q)
+
+        # Should work via fallback (dequantize → abs → return)
+        self.assertNotIsInstance(result, QuantizedTensor)
+        expected = torch.abs(a_fp32)
+        # FP8 introduces quantization error, so use loose tolerance
+        mean_error = (result - expected).abs().mean()
+        self.assertLess(mean_error, 0.05, f"Mean error {mean_error:.4f} is too large")
+
+
+if __name__ == "__main__":
+    unittest.main()